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Apalutamide Tablets

What is this medicine?

APALUTAMIDE (A-puh-LOO-tuh-mide) blocks the effect of the male hormone called testosterone. This medicine is used for certain types of prostate cancer.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • blood in the urine

  • chest pain

  • feeling faint or lightheaded, falls

  • seizures

  • shortness of breath

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • hot flashes

  • joint pain

  • nausea, vomiting

  • pain or trouble passing urine

  • swelling of the ankles, feet, hands

  • unusually weak or tired

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • artemether

  • certain antivirals for HIV or hepatitis like atazanavir, daclatasvir, doravirine, elbasvir; grazoprevir, fostemsavir, lopinavir, nelfinavir, paritaprevir, rilpivirine, ritonavir, and tipranavir

  • certain medicines for fungal infections like isavuconazonium and voriconazole

  • lorlatinib

  • lurasidone

  • praziquantel

  • ranolazine

This medicine may interact with the following medications:

  • gemfibrozil

  • certain medicines for fungal infections like ketoconazole and itraconazole

  • fexofenadine

  • midazolam

  • omeprazole

  • rosuvastatin

  • warfarin

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose and skip your missed dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • bone problems

  • brain tumor

  • diabetes

  • head injury

  • heart disease

  • high blood pressure

  • high cholesterol

  • history of stroke

  • seizures

  • an unusual or allergic reaction to apalutamide, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

This medicine should not be used in women. Men should not father a child while taking this medicine and for 3 months after stopping it. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

Due to a risk of seizures, use caution when engaging in activities that could result in serious harm to yourself or others if you pass out.

NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2020 Elsevier
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